Central Resistin Overexposure Induces Insulin Resistance Through Toll-Like Receptor 4

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Central Resistin Overexposure Induces Insulin Resistance Through Toll-Like Receptor 4

Resistin promotes both inflammation and insulin resistance associated with energy homeostasis impairment. However, the resistin receptor and the molecular mechanisms mediating its effects in the hypothalamus, crucial for energy homeostasis control, and key insulin-sensitive tissues are still unknown. In the current study, we report that chronic resistin infusion in the lateral cerebral ventricl...

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ژورنال

عنوان ژورنال: Diabetes

سال: 2012

ISSN: 0012-1797,1939-327X

DOI: 10.2337/db12-0237